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Cell Reports published the latest research of Prof. Cheguo Cai's team as cover article
?On Sep 13 2022, a research team led by Prof. CAl Cheguo, Medical Research Institute and Frontier Science Center for lmmunology and Metabolism of Wuhan University, just made progress in mammary stem cell (MaSC) and triple negative breast cancer (TNBC) research.Their work, “CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression”, published...
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New study from Prof. Haojian Zhang's laboratory reveals an important role of YBX1 in acute myeloid leukemia
?On March 24, 2021, the international renowned journal BLOOD published an article entitled "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner", reported the molecular mechanism of YBX1 in selectively regulating the survival of myeloid leukemia cells. This work came from Dr. Haojian Zhang’s laboratory. Dr. Zhang is a profess...
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Zhang, M., Zhang, L., Geng, A., …, Zeng, Y.A.*, Li, J.*, Cai, C.* (2022). CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression. Cell Rep. （蔡车国）AbstractThe Wnt/β-catenin signaling pathway plays an important role in regulating mammary organogenesis and oncogenesis. However, therapeutic methods targeting the Wnt pathway against breast ...
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Zeng, L.W., Feng, L., Liu, R., Lin, H., Shu, H.B., and Li, S.* (2022). The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Cell Mol Immunol.（李姝）AbstractInterleukin 5 (IL-5) plays crucial roles in type 2-high asthma by mediating eosinophil maturation, activation, chemotaxis and survival. Inhibition of...
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Chen, Y., Xu, W., Chen, Y., Han, A., Song, J., Zhou, X., and Song, W.* (2022). Renal NF-kappaB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting. Immunity.（宋威）AbstractTumor-induced host wasting and mortality are general phenomena across species. Many groups have previously demonstrated endocrinal impacts of malignant tumors on host wasting...
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Lan, X., Ding, S., Zhang, T., Yi, Y., Li, C., Jin, W., Chen, J., Liang, K., Wang, H., and Jiang, W.* (2022). PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression. Nat Commun 13, 4601.（蒋卫）AbstractPolycomb group (PcG) proteins are known to repress developmental genes during embryonic development and tissue homeostasis. Here, we report that P...
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Wang, J., Wang, A., Tian, K., Hua, X., Zhang, B., Zheng, Y., Kong, X., Li, W., Xu, L., Wang, J., Li, Z., Liu, Y.*, Zhou, Y.* (2022). A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors. Cell Discov 8, 74.（刘颖、周严）Abstractβ-catenin-dependent canonical Wnt signaling plays a plethora of roles in neocortex (Ncx) development, but its fu...
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Zhang, T., Zheng, R., Li, M., Yan, C., Lan, X., Tong, B., Lu, P., and Jiang, W.* (2022). Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Res 50, 4959-4973.（蒋卫）AbstractHuman endogenous retroviruses, also called LTR elements, can be bound by transcription factors and marked by different histone modifications i...
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